UBE1C

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3gene.[5][6]

UBA3
Available structures
PDB Ortholog search: PDBeRCSB
List of PDB id codes

1R4M, 1R4N, 1TT5, 1Y8X, 1YOV, 2LQ7, 2NVU, 3DBH, 3DBL, 3DBR, 3FN1, 3GZN

Identifiers
Aliases UBA3, NAE2, UBE1C, hubiquitin like modifier activating enzyme 3
External IDs OMIM: 603172MGI: 1341217HomoloGene: 2951GeneCards: UBA3
Gene location (Human)
Chr. Chromosome 3 (human)[1]

Band 3p14.1 Start 69,054,730 bp[1]
End 69,080,408 bp[1]
Gene location (Mouse)
Chr. Chromosome 6 (mouse)[2]

Band 6|6 D3 Start 97,183,670 bp[2]
End 97,205,647 bp[2]
RNA expression pattern
Bgee
Top expressed in
  • substantia nigra
  • heart
  • myocardium
  • blood
  • palpebral conjunctiva
  • corpus callosum
  • endometrium
  • kidney
  • thymus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
Species Human Mouse
Entrez

9039

22200

Ensembl

ENSG00000144744

ENSMUSG00000030061

UniProt

Q8TBC4

Q8C878

RefSeq (mRNA)

NM_003968
NM_198195
NM_198197
NM_001363861

NM_001111106
NM_001301857
NM_001301858
NM_001301859
NM_011666

RefSeq (protein)

NP_003959
NP_937838
NP_001350790

NP_001104576
NP_001288786
NP_001288787
NP_001288788
NP_035796

Location (UCSC) Chr 3: 69.05 – 69.08 Mb Chr 6: 97.18 – 97.21 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse
E2 binding domain

appbp1-uba3-nedd8, an e1-ubiquitin-like protein complex with atp
Identifiers
Symbol E2_bind
Pfam PF08825
InterPro IPR014929
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

This enzyme contains an E2 binding domain, which resembles ubiquitin, and recruits the catalytic core of the E2 enzyme UBE2M (Ubc12) in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.[7]

. . . UBE1C . . .

UBE1C has been shown to interact with NEDD8,[8]APPBP1[9] and UBE2M.[7]

  1. GRCh38: Ensembl release 89: ENSG00000144744Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030061Ensembl, May 2017
  3. “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Osaka F, Kawasaki H, Aida N, Saeki M, Chiba T, Kawashima S, Tanaka K, Kato S (August 1998). “A new NEDD8-ligating system for cullin-4A”. Genes Dev. 12 (15): 2263–8. doi:10.1101/gad.12.15.2263. PMC 317039. PMID 9694792.
  6. “Entrez Gene: UBE1C ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)”.
  7. Huang DT, Paydar A, Zhuang M, Waddell MB, Holton JM, Schulman BA (February 2005). “Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8’s E1”. Mol. Cell. 17 (3): 341–50. doi:10.1016/j.molcel.2004.12.020. PMID 15694336.
  8. Gong, L; Yeh E T (April 1999). “Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway”. J. Biol. Chem. UNITED STATES. 274 (17): 12036–42. doi:10.1074/jbc.274.17.12036. ISSN 0021-9258. PMID 10207026.
  9. Chen, Y; McPhie D L; Hirschberg J; Neve R L (March 2000). “The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons”. J. Biol. Chem. UNITED STATES. 275 (12): 8929–35. doi:10.1074/jbc.275.12.8929. ISSN 0021-9258. PMID 10722740.

. . . UBE1C . . .

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. . . UBE1C . . .

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