SUMF2

Sulfatase-modifying factor 2 is an enzyme that in humans is encoded by the SUMF2gene.[5][6]

SUMF2
Available structures
PDB Ortholog search: PDBeRCSB
List of PDB id codes

1Y4J

Identifiers
Aliases SUMF2, pFGE, sulfatase modifying factor 2
External IDs OMIM: 607940MGI: 1915152HomoloGene: 41037GeneCards: SUMF2
Gene location (Human)
Chr. Chromosome 7 (human)[1]

Band 7p11.2 Start 56,064,002 bp[1]
End 56,080,670 bp[1]
Gene location (Mouse)
Chr. Chromosome 5 (mouse)[2]

Band 5|5 G1.3 Start 129,846,986 bp[2]
End 129,864,050 bp[2]
RNA expression pattern
Bgee
Top expressed in
  • Body of pancreas
  • fallopian tube
  • thyroid gland
  • stomach
  • kidney
  • prostate
  • pancreas
  • islet of Langerhans
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
Species Human Mouse
Entrez

25870

67902

Ensembl

ENSG00000129103

ENSMUSG00000025538

UniProt

Q8NBJ7

Q8BPG6

RefSeq (mRNA)
NM_001042468
NM_001042469
NM_001042470
NM_001130069
NM_001130070

NM_001146333
NM_015411
NM_001366647
NM_001366648
NM_001366649

NM_026445

RefSeq (protein)
NP_001035934
NP_001035935
NP_001123541
NP_001139805
NP_056226

NP_001035933
NP_001353576
NP_001353577
NP_001353578

NP_080721

Location (UCSC) Chr 7: 56.06 – 56.08 Mb Chr 5: 129.85 – 129.86 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member – a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

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  1. GRCh38: Ensembl release 89: ENSG00000129103Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025538Ensembl, May 2017
  3. “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cosma MP, Pepe S, Annunziata I, Newbold RF, Grompe M, Parenti G, Ballabio A (May 2003). “The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases”. Cell. 113 (4): 445–56. doi:10.1016/S0092-8674(03)00348-9. PMID 12757706. S2CID 15095377.
  6. “Entrez Gene: SUMF2 sulfatase modifying factor 2”.

. . . SUMF2 . . .

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. . . SUMF2 . . .

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