ABI2

Abl interactor 2 also known as Abelson interactor 2 (Abi-2) is a protein that in humans is encoded by the ABI2gene.[5][6][7]

ABI2
Available structures
PDB Ortholog search: PDBeRCSB
List of PDB id codes

2ED0, 3P8C, 4N78

Identifiers
Aliases ABI2, ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB, abl-interactor 2, abl interactor 2, AIP1
External IDs OMIM: 606442MGI: 106913HomoloGene: 4209GeneCards: ABI2
Gene location (Human)
Chr. Chromosome 2 (human)[1]

Band 2q33.2 Start 203,328,239 bp[1]
End 203,447,728 bp[1]
Gene location (Mouse)
Chr. Chromosome 1 (mouse)[2]

Band 1|1 C2 Start 60,409,619 bp[2]
End 60,481,158 bp[2]
RNA expression pattern
Bgee
Top expressed in
  • dorsolateral prefrontal cortex
  • Brodmann area 23
  • putamen
  • nucleus accumbens
  • prosencephalon
  • caudate nucleus
  • Brodmann area 46
More reference expression data
BioGPS

More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
Species Human Mouse
Entrez

10152

329165

Ensembl

ENSG00000138443

ENSMUSG00000026782

UniProt

Q9NYB9

P62484

RefSeq (mRNA)

NM_001282925
NM_001282926
NM_001282927
NM_001282932
NM_005759

NM_001198570
NM_001198571
NM_198127

RefSeq (protein)
NP_001269854
NP_001269855
NP_001269856
NP_001269861
NP_005750

NP_001362591
NP_001362592
NP_001362593
NP_001362594
NP_001362595
NP_001362596
NP_001362597
NP_001362598
NP_001362599
NP_001362600
NP_001362601
NP_001362602
NP_001362603
NP_001362604
NP_001362605
NP_001362606
NP_001362607
NP_001362608
NP_001362609
NP_001362610
NP_001362611
NP_001362612
NP_001362613
NP_001362614
NP_001362615
NP_001362616
NP_001362617
NP_001362618
NP_001362619
NP_001362620
NP_001362621
NP_001362622
NP_001362624
NP_001362625
NP_001362627
NP_001362628
NP_001362631
NP_001362633
NP_001362635
NP_001362636
NP_001362637
NP_001362638
NP_001362639
NP_001362640
NP_001362641
NP_001362643
NP_001362646
NP_001362648
NP_001362650
NP_001362651
NP_001362652
NP_001362653
NP_001362654
NP_001362655
NP_001362656
NP_001362657
NP_001362658
NP_001362659
NP_001362660
NP_001362661
NP_001362662
NP_001362663
NP_001362664
NP_001362665
NP_001362666
NP_001362667
NP_001362668
NP_001362669
NP_001362670
NP_001362671
NP_001362672
NP_001362673
NP_001362674
NP_001362675
NP_001362676
NP_001362677
NP_001362678
NP_001362679
NP_001362680
NP_001362681
NP_001362682
NP_001362683
NP_001362684

NP_001185499
NP_001185500
NP_937760

Location (UCSC) Chr 2: 203.33 – 203.45 Mb Chr 1: 60.41 – 60.48 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

. . . ABI2 . . .

ABI2 has been shown to interact with ABL1,[5][8]ADAM19,[9] and TRIM32.[10]

  1. GRCh38: Ensembl release 89: ENSG00000138443Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026782Ensembl, May 2017
  3. “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dai Z, Pendergast AM (December 1995). “Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity”. Genes Dev. 9 (21): 2569–82. doi:10.1101/gad.9.21.2569. PMID 7590236.
  6. Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilarino Guell C, Aldred M, Brannon CA, Trembath RC, Nichols WC (September 2000). “A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium”. Genomics. 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
  7. “Entrez Gene: ABI2 abl interactor 2”.
  8. Cao C, Leng Y, Li C, Kufe D (April 2003). “Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response”. J. Biol. Chem. 278 (15): 12961–7. doi:10.1074/jbc.M300058200. PMID 12569093.
  9. Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C (September 2002). “Screen and identification of proteins interacting with ADAM19 cytoplasmic tail”. Mol. Biol. Rep. 29 (3): 317–23. doi:10.1023/A:1020409217215. PMID 12463424. S2CID 22611084.
  10. Kano S, Miyajima N, Fukuda S, Hatakeyama S (July 2008). “Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2”. Cancer Res. 68 (14): 5572–80. doi:10.1158/0008-5472.CAN-07-6231. PMID 18632609.

. . . ABI2 . . .

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. . . ABI2 . . .

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