Toledo was born in Ixtepec, Oaxaca, Mexico in 1970, and lives and works in Mexico City. Toledo is the daughter of Mexican artist Francisco Toledo. Her siblings include artist Dr. Lakra and poet Natalia Toledo.
She began as a photographer, and later incorporated drawing, painting, video, sound and sculpture into her work. From January to March 2009, she was an artist in residence at Gasworks, a contemporary art organisation in South London, UK. She has been on the artists council of and is a co-founder of SOMA, an educational art space in Mexico City which hosts international artists, curators, critics, and art historians in residential programs.
According to a SOMA Summer artist-in-residence description,
Laureana is inspired by the imperceptible or transient moments of the everyday, speculating on how such phenomena can gain new forms of visual presentation. Her work often involves systematic and repetitive interventions into different media (texts, books, photographs, painitngs, etc.) to re-code their existing narratives.