KIAA1279

KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279gene.[5] The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator.[6] Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis.[7] Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis,[8] and hence it can be therapeutically used to control Kif15 upregulated cancer cells.

KIFBP
Identifiers
Aliases KIFBP, KBP, KIAA1279, TTC20, KIF1 binding protein, kinesin family binding protein, KIF1BP
External IDs OMIM: 609367MGI: 1919570HomoloGene: 9223GeneCards: KIFBP
Gene location (Human)
Chr. Chromosome 10 (human)[1]

Band 10q22.1 Start 68,988,803 bp[1]
End 69,043,544 bp[1]
Gene location (Mouse)
Chr. Chromosome 10 (mouse)[2]

Band 10|10 B4 Start 62,538,626 bp[2]
End 62,578,457 bp[2]
RNA expression pattern
Bgee
Top expressed in
  • sural nerve
  • superior frontal gyrus
  • caudate nucleus
  • cerebellar hemisphere
  • prefrontal cortex
  • Brodmann area 9
  • myocardium
  • central nervous system
  • cerebral cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
Species Human Mouse
Entrez

26128

72320

Ensembl

ENSG00000198954

ENSMUSG00000036955

UniProt

Q96EK5

Q6ZPU9

RefSeq (mRNA)

NM_015634

NM_028197

RefSeq (protein)

NP_056449

NP_082473

Location (UCSC) Chr 10: 68.99 – 69.04 Mb Chr 10: 62.54 – 62.58 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

. . . KIAA1279 . . .

Defects may be associated with Goldberg–Shprintzen syndrome (OMIM 609460).

KIAA1279 has been shown to interact with Retinal G protein coupled receptor[9] and Dipeptidase 1.[9]

  1. GRCh38: Ensembl release 89: ENSG00000198954Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036955Ensembl, May 2017
  3. “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. “Entrez Gene: KIAA1279 KIAA1279”.
  6. Brouwers N, Mallol Martinez N, Vernos I (2017-04-26). “Role of Kif15 and its novel mitotic partner KBP in K-fiber dynamics and chromosome alignment”. PLOS ONE. 12 (4): e0174819. Bibcode:2017PLoSO..1274819B. doi:10.1371/journal.pone.0174819. PMC 5405935. PMID 28445502.
  7. Vanneste D, Takagi M, Imamoto N, Vernos I (November 2009). “The role of Hklp2 in the stabilization and maintenance of spindle bipolarity”. Current Biology. 19 (20): 1712–7. doi:10.1016/j.cub.2009.09.019. PMID 19818619.
  8. Sebastian J, Rathinasamy K (July 2019). “Benserazide Perturbs Kif15-kinesin Binding Protein Interaction with Prolonged Metaphase and Defects in Chromosomal Congression: A Study Based on in silico Modeling and Cell Culture”. Molecular Informatics. 39 (3): minf.201900035. doi:10.1002/minf.201900035. PMID 31347789. S2CID 198911009.
  9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

. . . KIAA1279 . . .

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. . . KIAA1279 . . .

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