YWHAG

14-3-3 protein gamma is a protein that in humans is encoded by the YWHAGgene.[5][6]

YWHAG
Available structures
PDB Ortholog search: PDBeRCSB
List of PDB id codes

2B05, 3UZD, 4E2E, 4J6S, 4O46, 5D3E

Identifiers
Aliases YWHAG, 14-3-3GAMMA, PPP1R170, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma, EIEE56, DEE56
External IDs OMIM: 605356MGI: 108109HomoloGene: 22725GeneCards: YWHAG
Gene location (Human)
Chr. Chromosome 7 (human)[1]

Band 7q11.23 Start 76,326,799 bp[1]
End 76,358,991 bp[1]
Gene location (Mouse)
Chr. Chromosome 5 (mouse)[2]

Band 5|5 G2 Start 135,908,409 bp[2]
End 135,934,616 bp[2]
RNA expression pattern
Bgee
Top expressed in
  • subthalamic nucleus
  • Brodmann area 23
  • pons
  • mesencephalon
  • spinal ganglia
  • brain
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
Species Human Mouse
Entrez

7532

22628

Ensembl

ENSG00000170027

ENSMUSG00000051391

UniProt

P61981

P61982

RefSeq (mRNA)

NM_012479

NM_018871

RefSeq (protein)

NP_036611

NP_061359

Location (UCSC) Chr 7: 76.33 – 76.36 Mb Chr 5: 135.91 – 135.93 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene product belongs to the 14-3-3 protein family which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.[7]

. . . YWHAG . . .

YWHAG has been shown to interact with C-Raf,[6][8][9]EPB41L3,[8][10]KIF1C[11] and Stratifin.[12]

  1. GRCh38: Ensembl release 89: ENSG00000170027Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000051391Ensembl, May 2017
  3. “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Horie M, Suzuki M, Takahashi E, Tanigami A (September 1999). “Cloning, expression, and chromosomal mapping of the human 14-3-3gamma gene (YWHAG) to 7q11.23”. Genomics. 60 (2): 241–3. doi:10.1006/geno.1999.5887. PMID 10486217.
  6. Autieri MV, Carbone CJ (July 1999). “14-3-3Gamma interacts with and is phosphorylated by multiple protein kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells”. DNA and Cell Biology. 18 (7): 555–64. doi:10.1089/104454999315105. PMID 10433554.
  7. “Entrez Gene: YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide”.
  8. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O’Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  9. Van Der Hoeven PC, Van Der Wal JC, Ruurs P, Van Dijk MC, Van Blitterswijk J (January 2000). “14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation”. The Biochemical Journal. 345 Pt 2 (2): 297–306. doi:10.1042/0264-6021:3450297. PMC 1220759. PMID 10620507.
  10. Yu T, Robb VA, Singh V, Gutmann DH, Newsham IF (August 2002). “The 4.1/ezrin/radixin/moesin domain of the DAL-1/Protein 4.1B tumour suppressor interacts with 14-3-3 proteins”. The Biochemical Journal. 365 (Pt 3): 783–9. doi:10.1042/BJ20020060. PMC 1222735. PMID 11996670.
  11. Dorner C, Ullrich A, Häring HU, Lammers R (November 1999). “The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family”. The Journal of Biological Chemistry. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.
  12. Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). “Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer”. Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.

. . . YWHAG . . .

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. . . YWHAG . . .

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