The stage version of Indian Ink had its first performance at the Yvonne Arnaud Theatre, Guildford, and opened at the Aldwych Theatre, London, on February 27, 1995. The production was directed by Peter Wood and designed by Carl Toms. 
The play had its American premiere in 1999 at the American Conservatory Theater (ACT) in San Francisco, California, directed by Carey Perloff (see 1999 in literature). The ACT production starred Jean Stapleton (Eleanor), Art Malik (Nirad), Susan Gibney (Flora), Firdous Bamji (Anish) and Ken Grantham (Eldon Pike).
The play received its East Coast premiere in 2000 at the Studio Theatre in Washington, DC., in a production starring Isabel Keating as Flora Crewe, a performance for which she received the Helen Hayes Award for Outstanding Lead Actress in a Resident Play.
The play was also produced in a critically acclaimed production in Chicago at The Apple Tree Theatre in June 2002, directed by Mark Lococo and starred Susie McMonagle (Flora), Peggy Roeder (Eleanor), Anish Jethmalani (Nirad), Paul Slade Smith (Eldon Pike), and Parvesh Cheena (Dilip).
The play was produced Off-Off-Broadway at Walkerspace in August 2003, directed by Ashok Sinha with Lethia Nall (Flora), Sendhil Ramamurthy (Nirad) and Helen-Jean Arthur (Eleanor).
The Roundabout Theatre Company produced Indian InkOff-Broadway in September 2014 to November 30, 2014 at the Laura Pels Theatre. Directed by Carey Perloff, the cast featured Rosemary Harris as Eleanor Swan, Romola Garai as Flora and Firdous Bamji as Nirad. The play was nominated for the 2015 Lucille Lortel Awards, Outstanding Costume Design (Candice Donnelly), Outstanding Revival, and Firdous Bamji won an Obie Award for his performance.New York Times critic, Ben Brantley, wrote that he should have been nominated for a Tony Award, but he was ineligible because the play was produced Off-Broadway. The ACT presented the play again in January and February 2015, with Perloff directing and the cast featured Roberta Maxwell (Eleanor), Brenda Meaney (Flora), Firdous Bamji (Nirad) and Pej Vahdat (Anish).